Univariate logistic regression analysis was used to identify potential variables that have an effect on hypermetabolism. J. Behav. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Act. Younossi Z, Anstee QM, Marietti M. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: A systematic review and meta-analysis. J. Physiol. Am. endobj Liver stiffness measurement (LSM) by vibration-controlled transient elastography and controlled attenuation parameter (CAP) measured by FibroScan device were combined with aspartate aminotransferase (AST), alanine aminotransferase (ALT), or AST:ALT ratio. Salmenniemi, U. et al. Call your healthcare provider if you have any questions. Liver inflammation. 11(Suppl), S208S217 (2001). /Contents 12 0 R The Fatty Liver Foundation, its officers or contributors expressly disclaim responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. Nat. It is important to remember that the ranges in the table are estimates, and your actual fibrosis score may not match what the table says. FOIA Why Your Doctor May Order a FibroScan - Northeast Digestive Article 14(2), 8898 (2018). Triangles represent deciles of participants (n=50) grouped by similar predicted risk. /Type /ExtGState The discrepancy is mainly driven by the intercept (CIs do not include zero). 8(9), 1387 (2019). Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV. stream Esser, N. et al. To use the table, find the liver disease that you have on the left side of the table. Ciardullo, S. & Perseghin, G. Statin use is associated with lower prevalence of advanced liver fibrosis in patients with type 2 diabetes. Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Classification and diagnosis of diabetes: Standards of medical care in diabetes. Publication Arslanow et al. Opin. Decision making for liver biopsy in NASH, not so FAST? /SMask /None>> This information will help you understand your FibroScan results. Adiponectin, alanine transaminase, physical activity, diastolic blood pressure and fat free mass were independently associated with hypermetabolism in subjects with NAFLD and T2DM. BMI was calculated as weight in kg divided by the square of height in meters. Nat Rev Gastroenterol Hepatol. This information will help you understand your FibroScan results. ADS The FAST score provides an efficient way to non-invasively identify patients at risk of progressive NASH for clinical trials or treatments when they become available, and thereby reduce unnecessary liver biopsy in patients unlikely to have significant disease. Scarring of the liver is measured by four stages. PubMed FibroScan will help your healthcare provider learn more about your liver disease. Exp. Although, historically, a negative relationship between obesity and REE has been shown32, recent studies have challenged this finding, indicating that obese individuals have higher BMR or REE33,34. 13(1), 112 (2021). PubMed Your results can range from normal to advanced. The data about demography, past medical history and drug consumption were collected through face-to-face interviews. The serum levels of insulin, C-peptide and thyroid-stimulating hormone (TSH) were determined by using ELISA kit (Monobind Inc., USA). Sports Sci. Echosens and UK National Institute for Health Research. Expert Rev. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (Fatty liver) 3. REE was measured by indirect calorimetry using a Fitmate calorimeter (Cosmed, Italy). FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study Echosens and UK National Institute for Health Research. Background: Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: All for one and one for all. CAS Inactivity and obesity are two of the biggest contributors to liver disease that is not due to heavy alcohol use. While we read all feedback, we cannot answer any questions. Over 34% but less than 66% is moderate, while over 66% is severe. Your result may be higher than the normal range if you have liver disease. Gastroenterol. Article Sci. Fatty liver? : I had a fibroscan - British Liver Trust - HealthUnlocked s -w64'?*TM|_*>&7VZG|Ze~_-c\;7b 4+T*=P *xtocd~ _t~D8, AuA? Google Scholar. Products in the FibroScanrange are Class IIa medical devices as defined by Directive 93/42/EEC (EC 0459). ADS Predicted REE was calculated using the HarrisBenedict equations30. suOhx>?oA\{G)Mght A FibroScan is a non-invasive diagnostic tool used to assess the health of your liver. /Pattern << CAP is unique, patented and validated for liver steatosis assessment 2,3: 822 international and peer-reviewed articles support the use of CAP. Transient elastography was performed by one experienced operator, using FibroScan 502 instrument (EchoSense, France, 5 MHz), to detect and quantify liver steatosis (CAP, dB/m) and fibrosis (LSM, kPa). The prediction of resting energy expenditure in type 2 diabetes mellitus is improved by factoring for glycemia. Int. Diagnostics (Basel). To explain these contradictions, the role of genetics as a factor that can influence both energy expenditure and adiponectin56,57, the use of different populations in studies, and the different methods used to assess energy expenditure must be taken into account. -, Sanyal AJ. Funding: This is based on your diagnosis, liver stiffness, and fibrosis scores. If you have more than one liver disease, you may not be able to use the table. Independent sample t-test, MannWhitney U test or Chi-square (2) test was used for comparison between groups as appropriate. -. Diabetes Care 40, S11S24 (2017). Publication Paul et al. 4) >> PLoS One. /Type /Page CAP is a guiding point for doctors and patients to improve monitoring of lifestyle change and therapeutic intervention.. CAP is a quantitative surrogate of liver steatosis expressed in decibel per meter (db/m). In the meantime, to ensure continued support, we are displaying the site without styles Hypertens. In another study, intracerebroventricular administration of adiponectin in mice induced UCP1 mRNA expression and decreasing the body weight, while not affecting the food intake62. Multiparametric US for Identifying Patients with High-Risk NASH: A Derivation and Validation Study. How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography-A Review of the Literature and Proposed Multistep Approach. You have a 6.2kpa which means you have fatty liver and you need to stop drinking and eat better immediately or it could lead to cirrhosis. Starling, R. D. Energy expenditure and aging: Effects of physical activity. A FibroScan is usually ordered for patients with medical conditions that can affect liver health, such as hepatitis B, hepatitis C, type 2 diabetes, and obesity. JJD, AP, M-HZ, PJE, DAS, ING, and VP declare no competing interests. Adv. CAS Fibrosis scores allow doctors to plan treatment. PMC Bitz, C. et al. Your care team cannot see anything you write on this feedback form. SAH reports grants from Conatus, Immuron, Second Genome, and Tobira/Allergan; grants and personal fees from Axcella, Cirius, CymaBay, Galmed, Gilead, HightTide, Intercept, NGM, Novartis, Novo Nordisk, Pfizer, Galectin, Genfit, and Madrigal; and personal fees from Metacrine, 3V Bio, Albereo, Alexion, Blade Therapeutics, Bristol-Myers Squibb, Civi BioPharma, CLDF, Contravir, Consynance, Concept, Echosens, Gelesis, HistoIndex, Innovate, IQVIA, Medpace, Perspectum, Poxel, Pometheus, Prometic, Terns, Akero, and Lipocine, outside the submitted work. Prevalence of NASH+NAS4+F2=9%. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. The site is secure. Can. Understanding your FibroScan Results - Abdi Waluyo Hospital To check the normality of continuous variables, the KolmogorovSmirnov test was applied. There is also evidence showing that resistance training programs increases REE71,72,73,74. Prevalence of, MeSH In patients with NAFLD and T2DM, hypermetabolism has a direct association with adiponectin, physical activity, ALT and diastolic blood pressure, but a diverse relationship with FFM. It measures fibrosis (scarring) and steatosis (fatty change) in your liver. Google Scholar. Physiol. Rehabil. J. Clin. To find the predictive factors that affected hypermetabolism in subjects with both T2DM and NAFLD, parameters with a p-value<0.2 in univariate analysis (data not shown), including sex, age, physical activity, AST, ALT, cholesterol, TNF-, adiponectin and FFM, were enteredinto the multivariate model. A fibroscan score is a numerical result between 2-75. If you have more than one liver disease, this table may not apply to you. >> B. et al. Med. 2012 Jul;32(6):911-8. doi: 10.1111/j.1478-3231.2012.02820.x. Endocrinol. This information should not be used as a substitute for professional diagnosis or treatment. Your FibroScan result will include measurements of the level of steatosis and scarring in your liver. According to the results of multivariable logistic regression analysis (Table 2), hypermetabolism was positively associated with adiponectin (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.021.34, p=0.030), physical activity (OR 1.13, 95% CI 1.0021.28, p=0.046), ALT (OR 1.06, 95% CI 1.0061.12, p=0.031) and diastolic blood pressure (OR 1.07, 95% CI 1.011.13, p=0.021). These devices are designed for use in a medical practice in order to measure liver stiffness and ultrasound attenuation in patients with liver disease. I called today my GI DR office again this was my 4th call asking what my CAP score was from my fibroscan. J. Obes. Calibration plots in external validation cohorts (A) French bariatric cohort (n=110). endobj Your healthcare provider will use your CAP score to find out your steatosis grade. My partner has been diagnosed with cirrhosis and had a second fibro scan on the 02/11 - his previous and first fibroscan KPa result was 29 it has risen to 44.2 in a matter of months - i am not sure what his previous CAP score was - does anyone know what stage of liver disease this is? This can happen if you have: FibroScan may give less accurate results, or no results at all if you have: Your healthcare provider may use imaging tests, such as ultrasound, CT, or MRI, to see your liver. Dial. Finally, FAST score performed least well in terms of calibration in low prevalence populations, and caution should be exercised when interpreting the score in these settings, although discrimination performance of the score was good. Disclaimer. The main causes of fatty liver disease are excessive alcohol consumption and/or poor diet and sedentary lifestyle. Methods: Tarantino, G. et al. Melby, C. et al. Therefore, this suggests that the elevated protein turnover, among other factors such as systemic inflammatory response, may be contributing to FFM depletion and increase REE levels in subjects with NALFD and diabetes. Mertens, J. et al. You are using a browser version with limited support for CSS. Background and Aims: FibroScan is used to determine liver stiffness and controlled attenuation parameter (referred to as CAP) scores in patients, including those with chronic hepatitis B (CHB). FibroScan is an imaging-based diagnostic test developed by Echosens that looks at liver fibrosis (stiffness, scarring) and steatosis (fat) using transient-elastography technology. It uses ultrasound technology to measure the stiffness of your liver tissue. In accordance with our findings, Ali et al.63 and Snodgrass et al.64 showed a direct relationship between BMR and blood pressure. >> Non-invasive means nothing is put inside your body. (C) China Hong-Kong NAFLD cohort (n=83). 2017;15:1120. In terms of drug consumption, there was a significant difference in the usage percentage of dipeptidyl peptidase 4 (DPP-4) inhibitors between the two groups (it was 51.6% in hypermetabolism subjects, while it was 15.6% in non-hypermetabolism subjects, p<0.001). Int. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. 2017, 18 (2017). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). W-KC reports personal fees from Boehringer Ingelheim, Echosens, and Mylan; grants from Sysmex and Resonance Health; and non-financial support from Endosurgery, outside the submitted work. Publication Paul et al. livers can have up to 5% of fatty changes in them. Huang, Z. et al. The FibroMeter NAFLD score was determined using a proprietary algorithm (regression score). Controlled attenuation parameter (CAP): a new device for fast evaluation of liver fat? Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. Araiza et al. Arrese, M. & Barrera, F. Concurrent nonalcoholic fatty liver disease and type 2 diabetes: Diagnostic and therapeutic considerations. Epub 2020 Dec 16. These measurements help your healthcare provider learn more about your liver disease. endobj 8600 Rockville Pike Effect of acute resistance exercise on postexercise energy expenditure and resting metabolic rate. CAP(Controlled Attenuation Parameter) is the non-invasive reference parameter to diagnose and monitor liver steatosis. Read across the row from left to right until you find the range that includes your fibrosis result. Examinations with FibroScandevice shall be performed by an operator who has been certified by the manufacturer or its approved local representative. The table below shows ranges of CAP scores and the matching steatosis grade and amount of fatty change. Nutr. Sci. Then, look at the top of that column to see the fibrosis score. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. Sabounchi, N. S., Rahmandad, H. & Ammerman, A. Best-fitting prediction equations for basal metabolic rate: Informing obesity interventions in diverse populations. J. Appl. Epub 2019 Jan 25. FibroScan Fat Results What does the FAT (CAP) Score mean? FibroScan with CAP for fatty liver disease assessment - Echosens Twenty-four-hour energy expenditure in Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. /Filter /FlateDecode BMR is defined as the amount of energy the body consumes at complete rest in a thermally neutral environment after 1012h of fasting and a night sleep18. Exerc. FibroScan has allowed doctors to learn more about the liver without resorting to invasive techniques, which is very efficient for purposes of monitoring. Understanding Your FibroScan Test Results - inSite Digestive Health Care The last column tells you how much scarring is in your liver. HHS Vulnerability Disclosure, Help Federal government websites often end in .gov or .mil. Berclaz, P.-Y. KPa score 44.2 CAP score 309 - Living with Fatty - HealthUnlocked Understanding Fibroscan Results - Centex Studies JFC was supported by the NIHR Oxford BRC. World J. Gastroenterol. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Asieh Mansour,Mohammad Reza Mohajeri-Tehrani&Sayed Mahmoud Sajjadi-Jazi, Asadabad School of Medical Sciences, Asadabad, Iran, Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran, Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, You can also search for this author in FAST=FibroScan-aspartate aminotransferase. A fibrosis score of F0 to F1 ( 2 to 7 kPa) means there is little or no scarring on the liver. The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD). FLF Launches a Public-Private Partnership to Combat the Silent Epidemic of NAFLD, FLF and Fibronostics form a patient education partnership, Echosens Aligns with FLF to Accelerate Screening for Undiagnosed NAFLD and NASH, Fatty Liver Foundation Launches the State of NAFLD/NASH Care in America Initiative to Support Improved Patient Care Experience, FATTY LIVER FOUNDATION TO MARK INTERNATIONAL NASH DAY WITH THREE INTERACTIVE PROGRAMS OFFERING INFORMATION, INSPIRATION, AND SUPPORT FOR PEOPLE AT-RISK OF OR LIVING WITH NAFLD/NASH. The LSM and CAP measurements are carried out simultaneously, and the median values of more than ten valid measurements are used to quantify liver . However, our study has some limitations. 678.750000 0] Intensity of resistance exercise determines adipokine and resting energy expenditure responses in overweight elderly individuals. Bethesda, MD 20894, Web Policies Ann. PubMed Would you like email updates of new search results? Liver biopsy is crucial for selecting patients with non-alcoholic steatohepatitis (NASH) for inclusion in clinical trials and, by implication, for treatment after new drugs are licensed. 2022 Nov 16;12(11):2822. doi: 10.3390/diagnostics12112822. You can read the sections below if you would like to learn more. A fibrosis score of F2 (7.5 to 10 kPa) indicates moderate scarring that has spread outside the liver. In addition, among biochemical markers, subjects with non-hypermetabolism had a significantly higher level of low-density lipoprotein cholesterol (LDL-C), as compared with hypermetabolic cases (98.00 [68.00118.00] vs. 71.00 [61.00105.00], p=0.041). Int. CD24 Gene Expression as a Risk Factor for Non-Alcoholic Fatty Liver Disease The median CAP was higher among patients with significant steatosis (317 [IQR 284-339] vs. 250 [227-279] dB/m with <10% steatosis; P < 0.0005) and the AUROC for this outcome was 0.81 (95% CI 0.74-0.88). FibroScan Detection of Fatty Liver/Liver Fibrosis in 2266 Cases of Nutrients. Liver Int. eCollection 2022. He decided to order a Fibroscan to rule out any liver disease. Your fibrosis result may be over-estimated (your liver may have less scarring than what your fibrosis result says) if you have: Your FibroScan results may also be less accurate if you have: Fibrosis score F0 to F1: No liver scarring or mild liver scarring, Fibrosis score F2: Moderate liver scarring, Fibrosis score F3: Severe liver scarring Fibrosis score. -, Haldar D, Kern B, Hodson J. Outcomes of liver transplantation for non-alcoholic steatohepatitis: a European Liver Transplant Registry study. Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography 2012 Jul;32(6):875-7. doi: 10.1111/j.1478-3231.2012.02824.x. Younossi, Z. M. et al. Nutrients 11(8), 1830 (2019). Waist circumference (WC) was measured at the midpoint between the lower costal margin and the iliac crest. If you are looking for a facility where you can get a Fibroscan, choose inSite Digestive Health Care. Epub 2011 Sep 15. Hypermetabolism was defined as an elevated measured REE>110% of the predicted REE. J. Clin. This means that your actual fibrosis score (the score that your healthcare provider tells you) may not match the fibrosis score in the table. Gastroenterology. Clin. Some studies have suggested that the diabetes per se, not the level of glucose level, is a major determinant of high REE in diabetic subjects37. Sport Nutr. However, to do so we need to know which prevalence would be representative of the population, in whom the score would be used, and a robust reference cohort with that low prevalence. >> Endocrinol. Triangles represent deciles of participants grouped by similar predicted risk. Transplant 17(2), 216221 (2002). Qi, Y. et al. 12, 20420188211055556 (2021). Fibroscan Score Fatty Liver CapFatty liver is a condition that causes the body's liver cells to swell up, known as fibrosis. Nephrol. Tarantino, G., Savastano, S. & Colao, A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. Diabetes Care 31(1), 165169 (2008). During the procedure, the doctor will place a small probe on your skin. If you have any questions or to schedule your Fibroscan, call our location nearest you or use our appointment request form. Deurenberg, P. Limitations of the bioelectrical impedance method for the assessment of body fat in severe obesity. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Understanding Your Liver Elastography (FibroScan) Results, All rights owned and reserved by Memorial Sloan Kettering Cancer Center, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Using Your Liver Stiffness Result to Find Your Fibrosis Score, Conditions That Can Affect Your Fibrosis Results, Non-alcoholic Fatty Liver Disease (NAFLD or NASH). Liver congestion (when your liver is too full of blood or other fluids). In those four cohorts, the FAST score overestimates the probability of being NASH+NAS4+F2. Get the latest news and updates on MSKs cancer care and research breakthroughs sent straight to your inbox with our e-newsletters. & Groop, L. Factors associated with basal metabolic rate in patients with type 2 (non-insulin-dependent) diabetes mellitus. << CAP value of 300 falls into S2/S3 stage. /Creator ( w k h t m l t o p d f 0 . Gastroenterol Hepatol Bed Bench. Article Zhou, M. et al. 1 0 obj A p-value<0.05 was considered statistically significant. doi: 10.1371/journal.pone.0266859. The shaded area indicates 95% CI. Correlation between Fibroscan and laboratory tests in non-alcoholic Plot of the screen failure rate (equal to 1positive predictive value) and missed cases rate (equal to 1sensitivity) versus all possible FAST score values. Am. /Length 13 0 R 34(2), 166170 (2018). Patel, P. J. et al. Calibration of the data is estimated using a smoothed regression line (dotted line) using locally estimated scatterplot smoothing (Loess) that allows inspection of the calibration across the range of predicted values and determination of whether there are segments of the range in which the model is poorly calibrated. 14(7), 837852 (2021). doi: 10.1093/crocol/otad004. I had a fibroscan done last month with a 17 Kpa (cirrhosis). Ultrasonography and FibroScan were performed twice and once, respectively ( Table 5 ). Non-alcoholic fatty liver disease: A major challenge in type 2 diabetes mellitus. Your healthcare provider will use your CAP score to find out your steatosis grade. See this image and copyright information in PMC. Sci Rep. 2022 Dec 19;12(1):21897. doi: 10.1038/s41598-022-25931-7. %PDF-1.4 These clinical trials aim to include those patients considered to be at greatest risk of disease progression and liver-related morbidity and mortality, factors that are defined by the presence and severity of liver fibrosis. Most patients with the presence of a metabolic syndrome. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography. Physiol. Gastroenterology. Careers. They may use blood tests or a certain type of MRI to measure scarring and fatty changes in your liver. CAS NASH+NAS4+F2=non-alcoholic steatohepatitis, elevated non-alcoholic fatty liver disease activity score (4) and advanced fibrosis (stage 2). There is a silent epidemic of fatty liver disease in the general population, called NAFLD/NASH. Luke, A. et al. Lancet Gastroenterol Hepatol. A. Advantages of CAP include its ease of measurement, operator-independence and simultaneous availability with LSM for fibrosis assessment. Rep. 5(6), 513520 (2003). Can Fibroscan Detect Fatty Liver cure fatty liver Nutr. Epub 2019 Jan 25. Accessibility PubMed Central National Library of Medicine -, Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. The exclusion criteria were as follows: being under insulin therapy, experiencing pregnancy or lactation, having the history of or currently drinking excessive alcohol (average drinking of alcohol over 20g/day26), viral hepatitis infection, having the history of thyroid disease or limb amputation, suffering from cardiovascular diseases, kidney diseases, cancer, mental disorders, cirrhosis and other chronic liver diseases, and currently consuming supplements including vitamin E and other antioxidants. Many people with liver disease(s) have a result that is higher than the normal range. Google Scholar. CAPis a quantitative surrogate of liver steatosis expressed in decibel per meter (db/m). Scientific Reports Correction to Lancet Gastroenterol Hepatol 2020; 5: 36273, Statement on offensive historical content, Time between FibroScan and liver biopsy, median (IQR); range, Time between FibroScan and blood analyses, median (IQR); range, Time between liver biopsy and blood analyses, median (IQR); range, Redistribute or republish the final article, Reuse portions or extracts from the article in other works. /XObject << When determining your actual fibrosis score, in addition to your fibrosis measurement, your provider will take into consideration your health history and the grade of steatosis. Find the liver disease you have in the first column on the left. CAPis available on the three FibroScan probes (S+*, M+ and XL+). Am. The enzyme-linked immunosorbent assay (ELISA) kit (Roche, Germany) was used to measure the serum concentration of liver enzymes, creatinine, high-sensitive C-reactive protein (hs-CRP) and lipids. >> The multivariate logistic regression test was used for detecting factors associated with hypermetabolism. Miele, L. et al. BMR has been reported to increase by 57% in individuals with T2DM21,22. In agreement with the previous reports69,70, our study indicated a positive association between physical activity and REE. The results of the present study showed a positive association between diastolic blood pressure and hypermetabolism. Zheng, Y., Ley, S. H. & Hu, F. B. CAS MathSciNet They are sending me for an MRI with elastography on Friday to confirm the staging. CAP is a guiding point for doctors and patients to improve monitoring of lifestyle change and therapeutic intervention. FibroScan is an imaging-based diagnostic test developed by Echosens that looks at liver fibrosis (stiffness, scarring) and steatosis (fat) using transient-elastography technology. The highest possible result is 75 kPa. FibroScan with CAP for fatty liver disease assessment - ECHOSENS 53(6), 529535 (2007). The dietary intervention has a positive impact on CAP. This cross-sectional study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Review Board at the Tehran University of Medical Sciences (IR.TUMS.MEDICINE.REC.1399.1281).